Structure and dynamics of Helicobacter pylori nickel-chaperone HypA: an integrated approach using NMR spectroscopy, functional assays and computational tools

Helicobacter pylori HypA (HpHypA) is a metallochaperone necessary for maturation of [Ni,Fe]-hydrogenase and urease, the enzymes required for colonization and survival of H. pylori in the gastric mucosa. HpHypA contains a structural Zn(II) site and a unique Ni(II) binding site at the N-terminus. X-ra...

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Publicado en:J Biol Inorg Chem
Main Authors: Spronk, Chris A. E. M., Żerko, Szymon, Górka, Michał, Koźmiński, Wiktor, Bardiaux, Benjamin, Zambelli, Barbara, Musiani, Francesco, Piccioli, Mario, Basak, Priyanka, Blum, Faith C., Johnson, Ryan C., Hu, Heidi, Merrell, D. Scott, Maroney, Michael, Ciurli, Stefano
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733409/
https://ncbi.nlm.nih.gov/pubmed/30264175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-018-1616-y
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