Structure and dynamics of Helicobacter pylori nickel-chaperone HypA: an integrated approach using NMR spectroscopy, functional assays and computational tools

Helicobacter pylori HypA (HpHypA) is a metallochaperone necessary for maturation of [Ni,Fe]-hydrogenase and urease, the enzymes required for colonization and survival of H. pylori in the gastric mucosa. HpHypA contains a structural Zn(II) site and a unique Ni(II) binding site at the N-terminus. X-ra...

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Gepubliceerd in:J Biol Inorg Chem
Hoofdauteurs: Spronk, Chris A. E. M., Żerko, Szymon, Górka, Michał, Koźmiński, Wiktor, Bardiaux, Benjamin, Zambelli, Barbara, Musiani, Francesco, Piccioli, Mario, Basak, Priyanka, Blum, Faith C., Johnson, Ryan C., Hu, Heidi, Merrell, D. Scott, Maroney, Michael, Ciurli, Stefano
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733409/
https://ncbi.nlm.nih.gov/pubmed/30264175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-018-1616-y
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