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Structure and dynamics of Helicobacter pylori nickel-chaperone HypA: an integrated approach using NMR spectroscopy, functional assays and computational tools

Helicobacter pylori HypA (HpHypA) is a metallochaperone necessary for maturation of [Ni,Fe]-hydrogenase and urease, the enzymes required for colonization and survival of H. pylori in the gastric mucosa. HpHypA contains a structural Zn(II) site and a unique Ni(II) binding site at the N-terminus. X-ra...

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Bibliografiske detaljer
Udgivet i:J Biol Inorg Chem
Main Authors: Spronk, Chris A. E. M., Żerko, Szymon, Górka, Michał, Koźmiński, Wiktor, Bardiaux, Benjamin, Zambelli, Barbara, Musiani, Francesco, Piccioli, Mario, Basak, Priyanka, Blum, Faith C., Johnson, Ryan C., Hu, Heidi, Merrell, D. Scott, Maroney, Michael, Ciurli, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733409/
https://ncbi.nlm.nih.gov/pubmed/30264175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-018-1616-y
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