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The long non-coding RNA lep-5 promotes the juvenile-to-adult transition by destabilizing LIN-28
Biological roles for most long non-coding RNAs (lncRNAs) remain mysterious. Here, using forward genetics, we identify lep-5, a lncRNA acting in the C. elegans heterochronic (developmental timing) pathway. Loss of lep-5 delays hypodermal maturation and male tail tip morphogenesis (TTM), hallmarks of...
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| Udgivet i: | Dev Cell |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6733259/ https://ncbi.nlm.nih.gov/pubmed/30956008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.03.003 |
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