The long non-coding RNA lep-5 promotes the juvenile-to-adult transition by destabilizing LIN-28

Biological roles for most long non-coding RNAs (lncRNAs) remain mysterious. Here, using forward genetics, we identify lep-5, a lncRNA acting in the C. elegans heterochronic (developmental timing) pathway. Loss of lep-5 delays hypodermal maturation and male tail tip morphogenesis (TTM), hallmarks of...

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Udgivet i:Dev Cell
Main Authors: Kiontke, Karin C., Herrera, R. Antonio, Vuong, Edward, Luo, Jintao, Schwarz, Erich M., Fitch, David H. A., Portman, Douglas S.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733259/
https://ncbi.nlm.nih.gov/pubmed/30956008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.03.003
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