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Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans

The heterochronic genes lin-28, let-7 and lin-41 regulate fundamental developmental transitions in animals, such as stemness versus differentiation and juvenile versus adult states. We identify a new heterochronic gene, lep-2, in Caenorhabditis elegans. Mutations in lep-2 cause a delay in the juveni...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Development
Main Authors: Herrera, R. Antonio, Kiontke, Karin, Fitch, David H. A.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813343/
https://ncbi.nlm.nih.gov/pubmed/26811380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.132738
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