Hydrogen sulfide inhibits Ca(2+)-induced mitochondrial permeability transition pore opening in type-1 diabetes

Hydrogen sulfide (H(2)S) attenuates N-methyl-d-aspartate receptor-R1 (NMDA-R1) and mitigates diabetic renal damage; however, the molecular mechanism is not well known. Whereas NMDA-R1 facilitates Ca(2+) permeability, H(2)S is known to inhibit L-type Ca(2+) channel. High Ca(2+) activates cyclophilin...

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Vydáno v:Am J Physiol Endocrinol Metab
Hlavní autoři: Papu John, A. Sashi, Kundu, Sourav, Pushpakumar, Sathnur, Amin, Matthew, Tyagi, Suresh C., Sen, Utpal
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732471/
https://ncbi.nlm.nih.gov/pubmed/31039005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00251.2018
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