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Hydrogen sulfide inhibits Ca(2+)-induced mitochondrial permeability transition pore opening in type-1 diabetes
Hydrogen sulfide (H(2)S) attenuates N-methyl-d-aspartate receptor-R1 (NMDA-R1) and mitigates diabetic renal damage; however, the molecular mechanism is not well known. Whereas NMDA-R1 facilitates Ca(2+) permeability, H(2)S is known to inhibit L-type Ca(2+) channel. High Ca(2+) activates cyclophilin...
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| Publicado no: | Am J Physiol Endocrinol Metab |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6732471/ https://ncbi.nlm.nih.gov/pubmed/31039005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00251.2018 |
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