FOXN3 hyperglycemic risk allele and insulin sensitivity in humans

OBJECTIVE: The rs8004664 variation within the FOXN3 gene is significantly and independently associated with fasting blood glucose in humans. We have previously shown that the hyperglycemia risk allele (A) increases FOXN3 expression in primary human hepatocytes; over-expression of human FOXN3 in zebr...

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Udgivet i:BMJ Open Diabetes Res Care
Main Authors: Erickson, Melissa L, Karanth, Santhosh, Ravussin, Eric, Schlegel, Amnon
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2019
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731827/
https://ncbi.nlm.nih.gov/pubmed/31543974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjdrc-2019-000688
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