Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation

Pu.1 is an ETS family transcription factor (TF) that plays critical roles in erythroid progenitors by promoting proliferation and blocking terminal differentiation. However, the mechanisms controlling expression and down-regulation of Pu.1 during early erythropoiesis have not been defined. In this s...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Willcockson, Michael A., Taylor, Samuel J., Ghosh, Srikanta, Healton, Sean E., Wheat, Justin C., Wilson, Tommy J., Steidl, Ulrich, Skoultchi, Arthur I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731665/
https://ncbi.nlm.nih.gov/pubmed/31431533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901122116
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