Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation

Pu.1 is an ETS family transcription factor (TF) that plays critical roles in erythroid progenitors by promoting proliferation and blocking terminal differentiation. However, the mechanisms controlling expression and down-regulation of Pu.1 during early erythropoiesis have not been defined. In this s...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Willcockson, Michael A., Taylor, Samuel J., Ghosh, Srikanta, Healton, Sean E., Wheat, Justin C., Wilson, Tommy J., Steidl, Ulrich, Skoultchi, Arthur I.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731665/
https://ncbi.nlm.nih.gov/pubmed/31431533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901122116
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