Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation

Pu.1 is an ETS family transcription factor (TF) that plays critical roles in erythroid progenitors by promoting proliferation and blocking terminal differentiation. However, the mechanisms controlling expression and down-regulation of Pu.1 during early erythropoiesis have not been defined. In this s...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Willcockson, Michael A., Taylor, Samuel J., Ghosh, Srikanta, Healton, Sean E., Wheat, Justin C., Wilson, Tommy J., Steidl, Ulrich, Skoultchi, Arthur I.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731665/
https://ncbi.nlm.nih.gov/pubmed/31431533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901122116
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