PKI-587 enhances chemosensitivity of oxaliplatin in hepatocellular carcinoma through suppressing DNA damage repair pathway (NHEJ and HR) and PI3K/AKT/mTOR pathway

Oxaliplatin resistance limits its effectiveness in the treatment of hepatocellular carcinoma (HCC). Abnormal activation of the PI3K/AKT/mTOR pathway has been associated with decreased survival of HCC patients, anti-apoptosis after chemotherapeutic drug-induced DNA damage, and chemoresistance. In thi...

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Veröffentlicht in:Am J Transl Res
Hauptverfasser: Zhang, Yinci, Xie, Chunmei, Li, Amin, Liu, Xueke, Xing, Yingru, Shen, Jing, Huo, Zhen, Zhou, Shuping, Liu, Xinkuang, Xie, Yinghai, Cao, Weiya, Ma, Yongfang, Xu, Ruyue, Cai, Shiyu, Tang, Xiaolong, Ma, Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731445/
https://ncbi.nlm.nih.gov/pubmed/31497229
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