BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy

Acquired resistance of hepatocellular carcinoma (HCC) to sorafenib (SFB) is the main reason for the failure of SFB treatment of the cancer. Abnormal activation of the PI3K/AKT/mTOR pathway is important in the acquired resistance of SFB. Therefore, we investigated whether BEZ235 (BEZ) could reverse a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biomed Res Int
Auteurs principaux: Cao, Weiya, Liu, Xueke, Zhang, Yinci, Li, Amin, Xie, Yinghai, Zhou, Shuping, Song, Li, Xu, Ruyue, Ma, Yongfang, Cai, Shiyu, Tang, Xiaolong
Format: Artigo
Langue:Inglês
Publié: Hindawi 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079203/
https://ncbi.nlm.nih.gov/pubmed/33987439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/5556306
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