BEZ235 enhances chemosensitivity of paclitaxel in hepatocellular carcinoma through inhibiting the PI3K/Akt/mTOR pathway

Desensitization of hepatocellular carcinoma (HCC) to paclitaxel chemotherapy is a major deterrent to successful treatment of the cancer. Abnormal activation of the PI3K/Akt/mTOR, pathway is a common outcome of chemotherapy for HCC. Therefore, we investigated whether BEZ235, a dual PI3K and mTOR inhi...

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Vydáno v:Am J Transl Res
Hlavní autoři: Liu, Xueke, Xie, Chunmei, Li, Amin, Zhang, Yinci, Liu, Xinkuang, Zhou, Shuping, Shen, Jing, Huo, Zhen, Cao, Weiya, Ma, Yongfang, Xu, Ruyue, Xing, Yingru, Xie, Yinghai, Cai, Shuyu, Tang, Xiaolong
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943462/
https://ncbi.nlm.nih.gov/pubmed/31934276
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