LY-294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF-1α pathway

Liver cancer remains one of the leading causes of cancer deaths worldwide. The therapeutic effect of oxaliplatin on liver cancer is often limited by acquired resistance of the cancer cells. Abnormal activation of the PI3K/AKT pathway plays an important role in the acquired resistance of oxaliplatin....

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Bibliographic Details
Published in:Mol Med Rep
Main Authors: Xu, Ruyue, Zhang, Yinci, Li, Amin, Ma, Yongfang, Cai, Wenpeng, Song, Li, Xie, Yinghai, Zhou, Shuping, Cao, Weiya, Tang, Xiaolong
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2021
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134878/
https://ncbi.nlm.nih.gov/pubmed/33982772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2021.12147
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