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Functional disease architectures reveal unique biological role of transposable elements

Transposable elements (TE) comprise roughly half of the human genome. Though initially derided as junk DNA, they have been widely hypothesized to contribute to the evolution of gene regulation. However, the contribution of TE to the genetic architecture of diseases remains unknown. Here, we analyze...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Hormozdiari, Farhad, van de Geijn, Bryce, Nasser, Joseph, Weissbrod, Omer, Gazal, Steven, Ju, Chelsea J. -T., Connor, Luke O’, Hujoel, Margaux L. A., Engreitz, Jesse, Hormozdiari, Fereydoun, Price, Alkes L.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731302/
https://ncbi.nlm.nih.gov/pubmed/31492842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11957-5
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