Desmoplasia and oncogene driven acinar-to-ductal metaplasia are concurrent events during acinar cell-derived pancreatic cancer initiation in young adult mice

The five-year survival rate of patients diagnosed with advanced pancreatic ductal adenocarcinoma (PDAC) has remained static at <5% despite decades of research. With the exception of erlotinib, clinical trials have failed to demonstrate the benefit of any targeted therapy for PDAC despite promisin...

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Vydáno v:PLoS One
Hlavní autoři: Johnson, Benjamin L., d’Alincourt Salazar, Marcela, Mackenzie-Dyck, Sarah, D’Apuzzo, Massimo, Shih, Hung Ping, Manuel, Edwin R., Diamond, Don J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731019/
https://ncbi.nlm.nih.gov/pubmed/31490946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221810
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