Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Rare genetic mutations in genes such as Parkin, Pink1, DJ-1, α-synuclein, LRRK2 and GBA are found to be responsible for the disease in about 15% of...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:PLoS Genet
Hlavní autoři: Giguère, Nicolas, Delignat-Lavaud, Benoît, Herborg, Freja, Voisin, Aurore, Li, Yuan, Jacquemet, Vincent, Anand-Srivastava, Madhu, Gether, Ulrik, Giros, Bruno, Trudeau, Louis-Éric
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730950/
https://ncbi.nlm.nih.gov/pubmed/31449520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008352
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky