Amphetamine maintenance therapy during intermittent cocaine self-administration in rats attenuates psychomotor and dopamine sensitization and reduces addiction-like behavior

D-amphetamine maintenance therapy shows promise as a treatment for people with cocaine addiction. Preclinical studies using Long Access (LgA) cocaine self-administration procedures suggest D-amphetamine may act by preventing tolerance to cocaine’s effects at the dopamine transporter (DAT). However,...

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Veröffentlicht in:Neuropsychopharmacology
Hauptverfasser: Allain, Florence, Delignat-Lavaud, Benoît, Beaudoin, Marie-Pierre, Jacquemet, Vincent, Robinson, Terry E., Trudeau, Louis-Eric, Samaha, Anne-Noël
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853073/
https://ncbi.nlm.nih.gov/pubmed/32682325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-020-0773-1
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