PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein

INTRODUCTION: Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1α, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as a possible therapeutic target for Parkinson’s dis...

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Foilsithe in:Acta Neuropathol Commun
Main Authors: Ciron, Carine, Zheng, Lu, Bobela, Wojciech, Knott, Graham W, Leone, Teresa C, Kelly, Daniel P, Schneider, Bernard L
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379693/
https://ncbi.nlm.nih.gov/pubmed/25853296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0200-8
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