Discovery of N-(2-Aminophenyl)-4-(bis(2-chloroethyl)amino)Benzamide as a Potent Histone Deacetylase Inhibitor

Inhibition of histone deacetylases (HDACs) has been an important emerging therapy for the treatment of multiple cancers. However, the application of HDAC inhibitors is restricted by the limited potency against solid tumors. In order to discover novel HDAC inhibitors with potent antitumor activities,...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhang, Lihui, Li, Xiaoyang, Chen, Yiming, Wan, Minghui, Jiang, Qixiao, Zhang, Li, Chou, C. James, Song, Weiguo, Zhang, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730478/
https://ncbi.nlm.nih.gov/pubmed/31543818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00957
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