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Design and Synthesis of Novel Hybrid Benzamide-Peptide Histone Deacetylase Inhibitors

We designed and synthesized a series of novel hybrid histone deacetylase inhibitors based on conjugation of benzamide-type inhibitors with either linear or cyclic peptides. Linear tetrapeptides (compounds 13 and 14), cyclic tetrapeptides (compounds 1 and 11), and heptanediamide-peptide conjugates (c...

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Detalhes bibliográficos
Main Authors: Hu, Fang, Chou, C. James, Gottesfeld, Joel M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045849/
https://ncbi.nlm.nih.gov/pubmed/19362838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.085
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