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Development of histone deacetylase inhibitors as therapeutics for neurological disease

Postsynthetic modifications of histone and other chromosomal proteins by reversible acetylation and/or methylation regulate many aspects of chromatin dynamics, such as transcription, replication and DNA repair. Aberrant modification states are associated with several neurological and neuromotor dise...

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Autors principals: Gottesfeld, Joel M, Pandolfo, Massimo
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824892/
https://ncbi.nlm.nih.gov/pubmed/20177429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fnl.09.55
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