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Pimelic Diphenylamide 106 Is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases

Histone deacetylase (HDAC) inhibitors, including various benzamides and hydroxamates, are currently in clinical development for a broad range of human diseases, including cancer and neurodegenerative diseases. We recently reported the identification of a family of benzamide-type HDAC inhibitors that...

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Detalles Bibliográficos
Main Authors: Chou, C. James, Herman, David, Gottesfeld, Joel M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602898/
https://ncbi.nlm.nih.gov/pubmed/18953021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807045200
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