Specific Inhibition of IκB Kinase Reduces Hyperalgesia in Inflammatory and Neuropathic Pain Models in Rats

Phosphorylation of IκB through IκB kinase (IKK) is the first step in nuclear factor κB (NF-κB) activation and upregulation of NF-κB-responsive genes. Hence, inhibition of IKK activity may be expected to prevent injury-, infection-, or stress-induced upregulation of various proinflammatory genes and...

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Vydáno v:J Neurosci
Hlavní autoři: Tegeder, Irmgard, Niederberger, Ellen, Schmidt, Ronald, Kunz, Susanne, Gühring, Hans, Ritzeler, Olaf, Michaelis, Martin, Geisslinger, Gerd
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2004
Témata:
Behavioral/Systems/Cognitive
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730471/
https://ncbi.nlm.nih.gov/pubmed/14973242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3118-03.2004
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