cGMP Produced by NO-Sensitive Guanylyl Cyclase Essentially Contributes to Inflammatory and Neuropathic Pain by Using Targets Different from cGMP-Dependent Protein Kinase I

A large body of evidence indicates that the release of nitric oxide (NO) is crucial for the central sensitization of pain pathways during both inflammatory and neuropathic pain. Here, we investigated the distribution of NO-sensitive guanylyl cyclase (NO-GC) in the spinal cord and in dorsal root gang...

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Pubblicato in:J Neurosci
Autori principali: Schmidtko, Achim, Gao, Wei, König, Peter, Heine, Sandra, Motterlini, Roberto, Ruth, Peter, Schlossmann, Jens, Koesling, Doris, Niederberger, Ellen, Tegeder, Irmgard, Friebe, Andreas, Geisslinger, Gerd
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671070/
https://ncbi.nlm.nih.gov/pubmed/18716216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2128-08.2008
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