cGMP Produced by NO-Sensitive Guanylyl Cyclase Essentially Contributes to Inflammatory and Neuropathic Pain by Using Targets Different from cGMP-Dependent Protein Kinase I

A large body of evidence indicates that the release of nitric oxide (NO) is crucial for the central sensitization of pain pathways during both inflammatory and neuropathic pain. Here, we investigated the distribution of NO-sensitive guanylyl cyclase (NO-GC) in the spinal cord and in dorsal root gang...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Schmidtko, Achim, Gao, Wei, König, Peter, Heine, Sandra, Motterlini, Roberto, Ruth, Peter, Schlossmann, Jens, Koesling, Doris, Niederberger, Ellen, Tegeder, Irmgard, Friebe, Andreas, Geisslinger, Gerd
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671070/
https://ncbi.nlm.nih.gov/pubmed/18716216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2128-08.2008
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