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Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I

cGMP-dependent protein kinase I (PKG-I) has been suggested to contribute to the facilitation of nociceptive transmission in the spinal cord presumably by acting as a downstream target of nitric oxide. However, PKG-I activators caused conflicting effects on nociceptive behavior. In the present study...

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Detalhes bibliográficos
Main Authors: Tegeder, Irmgard, Del Turco, Domenico, Schmidtko, Achim, Sausbier, Matthias, Feil, Robert, Hofmann, Franz, Deller, Thomas, Ruth, Peter, Geisslinger, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC365776/
https://ncbi.nlm.nih.gov/pubmed/14973199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0304076101
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