p53 Activation Domain 1 Is Essential for PUMA Upregulation and p53-Mediated Neuronal Cell Death

The p53 tumor suppressor gene has been implicated in the regulation of apoptosis in a number of different neuronal death paradigms. Because of the importance of p53 in neuronal injury, we questioned the mechanism underlying p53-mediated apoptosis in neurons. Using adenoviral-mediated gene delivery,...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Cregan, Sean P., Arbour, Nicole A., MacLaurin, Jason G., Callaghan, Steven M., Fortin, Andre, Cheung, Eric C. C., Guberman, Daniel S., Park, David S., Slack, Ruth S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2004
Schlagworte:
Cellular/Molecular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730234/
https://ncbi.nlm.nih.gov/pubmed/15525786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2114-04.2004
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