The c-Jun N-Terminal Protein Kinase Signaling Pathway Mediates Bax Activation and Subsequent Neuronal Apoptosis through Interaction with Bim after Transient Focal Cerebral Ischemia

The c-Jun N-terminal protein kinase (JNK) signaling pathway is implicated in neuronal apoptosis. The mechanism by which activated JNK induces neuronal apoptosis is strongly linked to mitochondrial apoptogenic proteins, although the molecular machinery downstream of JNK has not been precisely elucida...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Okuno, Shuzo, Saito, Atsushi, Hayashi, Takeshi, Chan, Pak H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2004
Schlagworte:
Neurobiology of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729938/
https://ncbi.nlm.nih.gov/pubmed/15356200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1745-04.2004
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