Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia

A novel specific inhibitor of c-Jun N-terminal kinase, 11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S), has a high affinity to JNK3 compared to JNK1/JNK2. The aim of this work was to study the mechanisms of neuroprotective activity of IQ-1S in the models of reversible focal cerebral isc...

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Published in:Cells
Main Authors: Plotnikov, Mark B., Chernysheva, Galina A., Smolyakova, Vera I., Aliev, Oleg I., Trofimova, Eugene S., Sherstoboev, Eugene Y., Osipenko, Anton N., Khlebnikov, Andrei I., Anfinogenova, Yana J., Schepetkin, Igor A., Atochin, Dmitriy N.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464312/
https://ncbi.nlm.nih.gov/pubmed/32784475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9081860
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