A Novel Dual NO-donating Oxime and c-Jun N-terminal Kinase Inhibitor Protects Against Cerebral Ischemia–Reperfusion Injury in Mice

The c-Jun N-terminal kinase (JNK) has been shown to be an important regulator of neuronal cell death. Previously, we synthesized the sodium salt of 11H-indeno[1,2-b]quinoxalin-11-one (IQ-1S) and demonstrated that it was a high-affinity inhibitor of the JNK family. In the present work, we found that...

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Vydáno v:Neurosci Lett
Hlavní autoři: Atochin, Dmitriy N., Schepetkin, Igor A., Khlebnikov, Andrei I., Seledtsov, Victor I., Swanson, Helen, Quinn, Mark T., Huang, Paul L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491393/
https://ncbi.nlm.nih.gov/pubmed/26923672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2016.02.033
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