Synthesis, Biological Evaluation, and Molecular Modeling of 11H-indeno[1,2-b]quinoxalin-11one Derivatives and Tryptanthrin-6-Oxime as c-Jun N-terminal Kinase Inhibitors

c-Jun N-terminal kinases (JNKs) play a central role in many physiologic and pathologic processes. We synthesized novel 11H-indeno[1,2-b]quinoxalin-11-one oxime analogs and tryptanthrin-6-oxime (indolo(2,1-b)quinazoline-6,12-dion-6-oxime) and evaluated their effects on JNK activity. Several compounds...

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Gepubliceerd in:Eur J Med Chem
Hoofdauteurs: Schepetkin, Igor A., Khlebnikov, Andrei I., Potapov, Andrei S., Kovrizhina, Anastasia R., Matveevskaya, Vladislava V., Belyanin, Maxim L., Atochin, Dmitry N., Zanoza, Svitlana O., Gaidarzhy, Nadiya M., Lyakhov, Sergiy A., Kirpotina, Liliya N., Quinn, Mark T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261293/
https://ncbi.nlm.nih.gov/pubmed/30347329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.10.023
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