Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA

Previously, we developed a proteolytically stable small molecule peptidomimetic termed D3 as a selective ligand of the extracellular domain of the TrkA receptor for the NGF. Ex vivo D3 was defined as a selective, partial TrkA agonist. Here, the in vivo efficacy of D3 as a potential therapeutic for c...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Bruno, Martin A., Clarke, Paul B. S., Seltzer, Alicia, Quirion, Rémi, Burgess, Kevin, Cuello, A. Claudio, Saragovi, H. Uri
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Behavioral/Systems/Cognitive
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729798/
https://ncbi.nlm.nih.gov/pubmed/15371501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1508-04.2004
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