Potent human p140-TrkA agonists derived from an anti-receptor monoclonal antibody

Monoclonal antibody (mAb) 5C3 directed against human p140 TrkA is a structural and functional mimic of nerve growth factor (NGF) and an artificial receptor agonist. mAb 5C3 binds in the NGF-docking site and, like NGF, it promotes TrkA internalization, TrkA and phosphatidylinositol-3 kinase tyrosine...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: LeSauteur, L, Maliartchouk, S, Le Jeune, H, Quirion, R, Saragovi, HU
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 1996
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6578545/
https://ncbi.nlm.nih.gov/pubmed/8778282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.16-04-01308.1996
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