An Attenuated Immune Response Is Sufficient to Enhance Cognition in an Alzheimer's Disease Mouse Model Immunized with Amyloid-β Derivatives

Immunization with amyloid-β (Aβ) 1-42 has been shown to reduce amyloid burden and improve cognition in Alzheimer's disease (AD) model mice. In a human trial, possible cognitive benefit was found but in association with significant toxicity in a minority of patients. We proposed that immunizatio...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Sigurdsson, Einar M., Knudsen, Elin, Asuni, Ayodeji, Fitzer-Attas, Cheryl, Sage, Daniel, Quartermain, David, Goni, Fernando, Frangione, Blas, Wisniewski, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729550/
https://ncbi.nlm.nih.gov/pubmed/15254082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1344-04.2004
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