Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy–Cataplexy in the Rat

The sleep disorder narcolepsy has been linked to loss of hypothalamic neurons producing the orexin (hypocretin) neuropeptides. Here, we report the generation of transgenic rats expressing a human ataxin-3 fragment with an elongated polyglutamyl stretch under control of the human prepro-orexin promot...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Beuckmann, Carsten T., Sinton, Christopher M., Williams, S. Clay, Richardson, James A., Hammer, Robert E., Sakurai, Takeshi, Yanagisawa, Masashi
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2004
Sujets:
Neurobiology of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729432/
https://ncbi.nlm.nih.gov/pubmed/15128861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5560-03.2004
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