Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy–Cataplexy in the Rat

The sleep disorder narcolepsy has been linked to loss of hypothalamic neurons producing the orexin (hypocretin) neuropeptides. Here, we report the generation of transgenic rats expressing a human ataxin-3 fragment with an elongated polyglutamyl stretch under control of the human prepro-orexin promot...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Beuckmann, Carsten T., Sinton, Christopher M., Williams, S. Clay, Richardson, James A., Hammer, Robert E., Sakurai, Takeshi, Yanagisawa, Masashi
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729432/
https://ncbi.nlm.nih.gov/pubmed/15128861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5560-03.2004
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