Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy–Cataplexy in the Rat

The sleep disorder narcolepsy has been linked to loss of hypothalamic neurons producing the orexin (hypocretin) neuropeptides. Here, we report the generation of transgenic rats expressing a human ataxin-3 fragment with an elongated polyglutamyl stretch under control of the human prepro-orexin promot...

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發表在:J Neurosci
Main Authors: Beuckmann, Carsten T., Sinton, Christopher M., Williams, S. Clay, Richardson, James A., Hammer, Robert E., Sakurai, Takeshi, Yanagisawa, Masashi
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2004
主題:
Neurobiology of Disease
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729432/
https://ncbi.nlm.nih.gov/pubmed/15128861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5560-03.2004
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