Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy–Cataplexy in the Rat

The sleep disorder narcolepsy has been linked to loss of hypothalamic neurons producing the orexin (hypocretin) neuropeptides. Here, we report the generation of transgenic rats expressing a human ataxin-3 fragment with an elongated polyglutamyl stretch under control of the human prepro-orexin promot...

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Pubblicato in:J Neurosci
Autori principali: Beuckmann, Carsten T., Sinton, Christopher M., Williams, S. Clay, Richardson, James A., Hammer, Robert E., Sakurai, Takeshi, Yanagisawa, Masashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2004
Soggetti:
Neurobiology of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729432/
https://ncbi.nlm.nih.gov/pubmed/15128861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5560-03.2004
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