Age-Dependent Neurodegeneration and Alzheimer-Amyloid Plaque Formation in Transgenic Drosophila

β-Amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical role in Alzheimer's disease (AD) pathophysiology. Here, we show that in Drosophila, the targeted expression of the key genes of AD, APP, theβ-site APP-cleaving enzyme BACE, and the presenilins led to th...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Greeve, Isabell, Kretzschmar, Doris, Tschäpe, Jakob-Andreas, Beyn, Anika, Brellinger, Claire, Schweizer, Michaela, Nitsch, Roger M., Reifegerste, Rita
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2004
Fag:
Neurobiology of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729409/
https://ncbi.nlm.nih.gov/pubmed/15102905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0283-04.2004
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