Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic Mice

Alzheimer's disease (AD), the most common neurodegenerative disorder, results in progressive degeneration of synapses and aberrant sprouting of axon terminals. The mechanisms underlying these seemingly opposing cellular phenomena are unclear. We hypothesized that Fyn kinase may play a role in o...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Chin, Jeannie, Palop, Jorge J., Yu, Gui-Qiu, Kojima, Nobuhiko, Masliah, Eliezer, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729387/
https://ncbi.nlm.nih.gov/pubmed/15140940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0277-04.2004
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