Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

We used primary cultures of cortical neurons to examine the relationship between β-amyloid toxicity and hyperphosphorylation of the tau protein, the biochemical substrate for neurofibrillary tangles of Alzheimer's brain. Exposure of the cultures to β-amyloid peptide (βAP) induced the expression...

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Vydáno v:J Neurosci
Hlavní autoři: Caricasole, Andrea, Copani, Agata, Caraci, Filippo, Aronica, Eleonora, Rozemuller, Annemieke J., Caruso, Alessandra, Storto, Marianna, Gaviraghi, Giovanni, Terstappen, Georg C., Nicoletti, Ferdinando
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2004
Témata:
Neurobiology of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729239/
https://ncbi.nlm.nih.gov/pubmed/15229249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1381-04.2004
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