DNA Polymerase-β Is Expressed Early in Neurons of Alzheimer's Disease Brain and Is Loaded into DNA Replication Forks in Neurons Challenged with β-Amyloid

Cultured neurons exposed to synthetic β-amyloid (Aβ) fragments reenter the cell cycle and initiate a pathway of DNA replication that involves the repair enzyme DNA polymerase-β (DNA pol-β) before undergoing apoptotic death. In this study, by performing coimmunoprecipitation experiments on cross-link...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Copani, Agata, Hoozemans, Jeroen J. M., Caraci, Filippo, Calafiore, Marco, Van Haastert, Elise S., Veerhuis, Robert, Rozemuller, Annemieke J. M., Aronica, Eleonora, Sortino, Maria Angela, Nicoletti, Ferdinando
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674652/
https://ncbi.nlm.nih.gov/pubmed/17065437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2793-06.2006
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