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Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank

Insulin drives growth and reproduction which trade-off against longevity. Genetically predicted insulin, i.e., insulin proxied by genetic variants, is positively associated with ischemic heart disease, but sex differences are unclear, despite different disease rates and reproductive strategies by se...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Zhao, Jie V., Luo, Shan, Schooling, C. Mary
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728387/
https://ncbi.nlm.nih.gov/pubmed/31508506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0579-z
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