Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer

Stabilization of the MYC oncoprotein by KRAS signaling is a requirement for growth of pancreatic ductal adenocarcinomas (PDAC). However, current understanding of how MYC protein stability is regulated in MYC-dependent cancers such as KRAS-mutant PDAC is incomplete. We developed a flow cytometry-base...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Blake, Devon R., Vaseva, Angelina V., Hodge, Richard G., Kline, McKenzie P., Gilbert, Thomas S.K., Tyagi, Vikas, Huang, Daowei, Whiten, Gabrielle C., Larson, Jacob E., Wang, Xiaodong, Pearce, Kenneth H., Herring, Laura E., Graves, Lee M., Frye, Stephen V., Emanuele, Michael J., Cox, Adrienne D., Der, Channing J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728149/
https://ncbi.nlm.nih.gov/pubmed/31311847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav7259
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