KRAS Suppression-Induced Degradation of MYC is Antagonized by a MEK5-ERK5 Compensatory Mechanism

Our recent ERK1/2 inhibitor analyses in pancreatic ductal adenocarcinoma (PDAC) indicated ERK1/2-independent mechanisms maintaining MYC protein stability. To identify these mechanisms, we determined the signaling networks by which mutant KRAS regulates MYC. Acute KRAS suppression caused rapid protea...

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Pubblicato in:Cancer Cell
Autori principali: Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321749/
https://ncbi.nlm.nih.gov/pubmed/30423298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.001
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