A feedback loop between hypoxia and matrix stress relaxation increases oxygen-axis migration and metastasis in sarcoma

Upregulation of collagen matrix cross-linking directly increases its ability to relieve stress under the constant strain imposed by solid tumor, a matrix property termed stress relaxation. However, it is unknown how rapid stress relaxation in response to increased strain impacts disease progression...

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Publicado en:Cancer Res
Autores principales: Lewis, Daniel M., Pruitt, Hawley, Jain, Nupur, Ciccaglione, Mark, McCaffery, J. Michael, Xia, Zhiyong, Weber, Kristy, Eisinger-Mathason, T. S. Karin, Gerecht, Sharon
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727644/
https://ncbi.nlm.nih.gov/pubmed/30777851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1984
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