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Three Autocrine Feedback Loops Determine HIF1α Expression in Chronic Hypoxia
Hypoxia occurs in cancer, prolonged exercise, and long-term ischemia with durations of several hours or more, and the hypoxia-inducible factor 1 (HIF1) pathway response to these conditions differs from responses to transient hypoxia. We used computational modeling, validated by experiments, to gain...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2094118/ https://ncbi.nlm.nih.gov/pubmed/17720260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2007.07.004 |
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