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Determinants of Orexin Receptor Binding and Activation—A Molecular Dynamics Study

[Image: see text] We assess the stability of two previously suggested binding modes for the neuropeptide orexin-A in the OX(2) receptor through extensive molecular dynamics simulations. As the activation determinants of the receptor remain unknown, we simulated an unliganded receptor and two small-m...

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Detaylı Bibliyografya
Yayımlandı:J Phys Chem B
Asıl Yazarlar: Karhu, Lasse, Magarkar, Aniket, Bunker, Alex, Xhaard, Henri
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2019
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727383/
https://ncbi.nlm.nih.gov/pubmed/30786708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.8b10220
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