Wild-type TP53 defined gamma-secretase inhibitor sensitivity and synergistic activity with doxorubicin in GSCs

Glioblastoma (GBM) is the most common and lethal primary intracranial tumor. Aggressive surgical resection plus radiotherapy and temozolomide have prolonged patients’ median survival to only 14.6 months. Therefore, there is a critical need to develop novel therapeutic strategies for GBM. In this stu...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Zhang, Chen, Martinez-Ledesma, Emmanuel, Gao, Feng, Zhang, Wei, Ding, Jie, Wu, Shaofang, Li, Xiaolong, Wu, Jimin, Yuan, Ying, Koul, Dimpy, Alfred Yung, WK
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726980/
https://ncbi.nlm.nih.gov/pubmed/31497354
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