Structural adaptation in its orphan domain engenders betaglycan with an alternate mode of growth factor binding relative to endoglin

Betaglycan (BG) and endoglin (ENG), homologous co-receptors of the TGF-β family, potentiate the signaling activity of TGF-β2 and inhibin A, and BMP-9 and −10, respectively. BG exists as monomer and forms 1:1 growth factor (GF) complexes, while ENG exists as a dimer and forms 2:1 GF complexes. Herein...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Kim, Sun Kyung, Whitley, Matthew J., Krzysiak, Troy C., Hinck, Cynthia S., Taylor, Alexander B., Zwieb, Christian, Byeon, Chang-Hyeock, Zhou, Xiaohong, Mendoza, Valentín, López-Casillas, Fernando, Furey, William, Hinck, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726503/
https://ncbi.nlm.nih.gov/pubmed/31327662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.06.010
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