TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α

Betaglycan (BG) is a membrane-bound co-receptor of the TGF-β family that selectively binds transforming growth factor-β (TGF-β) isoforms and inhibin A (InhA) to enable temporal-spatial patterns of signaling essential for their functions in vivo. Here, using NMR titrations of methyl-labeled TGF-β2 wi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Henen, Morkos A., Mahlawat, Pardeep, Zwieb, Christian, Kodali, Ravindra B., Hinck, Cynthia S., Hanna, Ramsey D., Krzysiak, Troy C., Ilangovan, Udayar, Cano, Kristin E., Hinck, Garrett, Vonberg, Machell, McCabe, Megan, Hinck, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398128/
https://ncbi.nlm.nih.gov/pubmed/30598510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005210
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