Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors

Coordinated conformational transitions in oligomeric enzymatic complexes modulate function in response to substrates and play a crucial role in enzyme inhibition and activation. Caseinolytic protease (ClpP) is a tetradecameric complex, which has emerged as a drug target against multiple pathogenic b...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Felix, Jan, Weinhäupl, Katharina, Chipot, Christophe, Dehez, François, Hessel, Audrey, Gauto, Diego F., Morlot, Cecile, Abian, Olga, Gutsche, Irina, Velazquez-Campoy, Adrian, Schanda, Paul, Fraga, Hugo
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726451/
https://ncbi.nlm.nih.gov/pubmed/31517045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw3818
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